Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.
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چکیده
منابع مشابه
Type 2C protein phosphatases in fungi.
Type 2C Ser/Thr phosphatases are a remarkable class of protein phosphatases, which are conserved in eukaryotes and involved in a large variety of functional processes. Unlike in other Ser/Thr phosphatases, the catalytic polypeptide is not usually associated with regulatory subunits, and functional specificity is achieved by encoding multiple isoforms. For fungi, most information comes from the ...
متن کاملDephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases.
Activating phosphorylation of cyclin-dependent protein kinases (CDKs) is necessary for their kinase activity and cell cycle progression. This phosphorylation is carried out by the Cdk-activating kinase (CAK); in contrast, little is known about the corresponding protein phosphatase. We show that type 2C protein phosphatases (PP2Cs) are responsible for this dephosphorylation of Cdc28p, the major ...
متن کاملProtein Phosphatases Targeted Library
Preamble Phosphatases constitute a wide class of enzymes which remove a phosphate group from the target substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group. This action is directly opposite to that of phosphorylases and kinases. While kinases phosphorylate cellular substrates by using energetic molecules like ATP, phosphatases, in t...
متن کاملMetaplastic protein phosphatases.
Activity-dependent synaptic plasticity is widely considered to be one of the cellular mechanisms that underlie learning and memory. Long-term potentiation (LTP) is the most intensely studied form of synaptic plasticity, in part because it can be induced at glutamatergic synapses in the mammalian brain, including the hippocampus, a structure known for its involvement in memory function. LTP can ...
متن کاملPhosphotyrosyl protein phosphatases.
Enzyme-catalysed reversible protein phosphorylation is an important cellular regulatory mechanism (Nimmo & Cohen, 1977; Krebs & Beavo, 1979). Regulatory protein phosphorylation occurs most frequently on seryl and threonyl residues (Taborsky, 1974), and less frequently, on tyrosyl residues (Hunter, 1982). Protein phosphotyrosine [Tyr(P)] normally accounts for only 0.01-0.050o of the total protei...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)46657-9